New cassane diterpenes from Caesalpinia echinata.

نویسندگان

  • Betania Barros Cota
  • Djalma Menezes de Oliveira
  • Ezequias Pessoa de Siqueira
  • Elaine Maria Souza-Fagundes
  • Adriano M C Pimenta
  • Daniel M Santos
  • Ana Rabello
  • Carlos Leomar Zani
چکیده

An investigation of the ethanolic extract from stems of Caesalpinia echinata Lam (Leguminosae-Caesalpinioideae) led to the isolation of five new cassane diterpenes along with known lambertianic acid. Their structures were determined based on spectroscopic methods. A preliminary study on leishmanicidal activity demonstrated that compounds 1, 2 and 6 were found to inhibit the growth of amastigote-like forms of Leishmania amazonensis without affecting mononuclear cells obtained from human peripheral blood.

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عنوان ژورنال:
  • Fitoterapia

دوره 82 7  شماره 

صفحات  -

تاریخ انتشار 2011